Sam-E (S-adenosylmethionine) is substrate involved in methyl group transfers and more. Typically, we see great results with anxiety, depression (especially adrenal and stress related), fibromyalgia, osteoarthritis pain, PMS as well as aiding in liver detoxifying. In the Cochrane Database of Systematic Reviews (2009), multiple researchers found SAM-e was excellent in reducing pain and improving osteoarthritis function.